Generic nameMetamizole sodium (Dipyrone)
Each tablet contains:
active ingredient: metamizole sodium–500 mg;
inactive ingredients: microcrystalline cellulose, lactose monohydrate, maize starch, sodium starch glycolate, magnesium stearate, talc purified.
Analgin (metamizole) is a medicine of the pyrazolone group, possessing hard analgesic and antipyretic effects and moderate antiinflammatory activity. Blocking of the synthesis of endogenous pyrogens – prostaglandins D and E – is the cause for the antipyretic activity and also for the analgesic action of this drug. The decrease of the prostaglandis production in the periphery (and respective decrease of nerve endings sensitivity) plays a relatively smaller role. In contrast to the other nonnarcotic analgesic drugs, metamizole stimulates the release of β-endorphins, explaining its activity in cases of visceral pain. Metamizole has a slight spasmolytic activity on the smooth muscle cells of the biliary and urinary tracts and also on the muscle of the uterus.
After oral doses metamizole is rapidly hydrolysed in gastric juice to the active metabolite 4-methyl-amino-antipyrine which after absorption undergoes metabolism to 4-methyl-amino-antipyrine and other metabolites. None of the metabolites of metamizole are extensively bound to plasma proteins. Most of a dose is excreted in the urine as metabolites. Metamizole metabolites are also distributed into breast milk.
Action develops in 20-40 minutes and reaches to the maximum after 2 h.
Analgin tablets are used for the treatment of pains of different origin and variable intensity:
-toothache, headache, arthralgia, neuralgia, myalgia (in case of other analgesic medications inefficiency);
-fever with colds and infectious-inflammatory diseases.
The dosage and duration of the treatment must be determined according to the severity of the pain syndrome. The common dose in the adults is 250 to 500 mg (1/2 to 1 tablet) ), every 8-12 hour. The maximum single dose – 1 g, and 3 g/daily. In over 15 year-old children the Analgin dose is 250 mg (1/2-1 tab), every 8-12 hours.
Possible decrease in blood pressure, heart rhythm disturbances.
Treatment: induction of vomiting, gastric lavage through probe, laxatives appointment, activated carbon and conducting forced diuresis, alkalization of blood, symptomatic therapy aimed at maintaining vital functions.
Infrom your doctor if the patient suffers from one of the above mentioned diseases or uses other preparations.
Effects on ability to drive vehicles and management mechanisms
After receiving Analgin breastfeeding should be discontinued for 48 hours.
Store at temperature not higher than 250C, out of the reach of children, in original pack.