Blood and lymphatic system disorders: anaemia (including aplastic and haemolytic), agranulocytosis, pancytopenia, leukocytosis, eosinophilia, neutropenia, leukopenia, hypogammaglobulinemia.
Metabolic and nutrition disorders: hypoglycemia.
Nervous system disorders: depression,ataxia,anxiety, dysesthesia, somnolence, insomnia, nervousness, paraesthesia, , sleep disorders.
From the sensory organs very common: blurred vision, disturbance of taste and smell, tinnitus, conjunctivitis, dryness of the conjunctiva, lacrimation.
Cardiac and vascular disorders: hypotension, myocardial infarction or cerebrovascular accident, rhythm disorders, angina pectoris,cardiac arrest, orthostatic hypotension, palpitations, Raynaud’s syndrome.
Respiratory, thoracic and mediastinal disorders: pulmonary embolism, hoarseness, bronchospasm, asthma, pneumonia, pulmonary infiltrates,sinusitis, pharyngitis, rhinitis, eosinophilic pneumoniapulmonary infarction, pulmonary edema, respiratory distress,including pneumonitis and pulmonary edema.
Gastrointestinal disorders: nausea, diarrhoea, abdominal pain, ileus, pancreatitis, vomiting, constipation, anorexia, intestinal colics, dry mouth, salivary glands inflammation, meteorism, stomatitis, glossitis.
Hepatobiliary disorders: hepatic failure, hepatitis – either hepatocellular or cholestatic, hepatitis including necrosis, elevated liver enzymes, hyperbilirubinemia, jaundice, мmelena, cholestasis (including jaundice).
Skin and subcutaneous tissue disorders and allergic reactions: rash, photosensitivity, hypersensitivity, angioneurotic oedema (angioneurotic oedema of the face, extremities, lips, tongue, glottis and/or larynx has been reported), pruritus, urticaria, alopecia, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis, anaphylactic reactions.
Renal and urinary disorders: renal dysfunction, renal failure, interstitial nephritis, oliguria.
Reproductive system and breast disorders: impotence, gynaecomastia.
Investigations: hyperkalaemia, hyponatraemia, hypochloremic alkalosis, hyperglycemia, glycosuria, hyperuricemia, hypercholesterolemia, hypertriglyceridemia.
Others: increased sweating, tinea, lupus-like syndrome (fever, myalgia, and arthralgia, serositis, vasculitis, increased erythrocyte sedimentation rate, leukocytosis and eosinophilia, skin rash, a positive test for antinuclear antibodies), fever, weakness, thrombocytopenic purpura, necrotizing vasculitis.