Drug formEye ointments
ATC subcategoryTopical ophthalmic antimicrobial agents
Each of 100 gram of Tetracycline 1% eye ointment contains:
active ingredient: Tetracycline-1g;
excipients:Lanolin anhydrous – 40g, petrolatum ophtalmic –to 100g.
Spectrum of activity
The tetracyclines are mainly bacteriostatic, with a broad spectrum of antimicrobial activity. The following Gram-positive and Gram-negative pathogenic bacteria are usually sensitive to tetracyclines: Staphylococcus aureus, Streptococcus pneumoniae, Listeria spp., Bacillus anthracis, Clostridium spp., Actinomyces israelii; Haemophilus influenzae, Haemophilus ducreyi, Bordetella pertussis, enterobacteria (Escherichia coli, Enterobacter spp., Enterobacter aerogenes, Klebsiella spp., Salmonella spp., Shigella spp., Yersinia pestis, Bartonella bacilliformis, Vibrio cholerae, Vibrio fetus, Rickettsia spp., Borrelia burgdorferi, Brucella spp.
Mechanism of action
Tetracyclines are taken up into sensitive bacterial cells by an active transport process. Once appeared within the cell, they reversibly affiliate to the 30S subunit of the ribosome in bacterial cells. Consequently they prevent the binding of aminoacyl transfer RNA and inhibit the protein synthesis and hence cell growth of. The synthesis of proteins in mammalian cells is also inhibited although tetracyclines. That is why tetracyclines are not actively taken up by bacterial cells, thereby they permit the selective activity against the infecting organisms.
Tetracycline 1% eye ointment is indicated for treatment of superficial ophthalmic infections – and is administered as a topical ointment application to the lid.
Neonatal chlamydial and gonococcal conjunctivitis and uncomplicated bacterial conjunctivitis may be self-limiting but empirical treatment with topical tetracycline antibacterials. In neonatals drug should be applied to the conjuctiva as a thin strip (approximately1sm) as a single daily dose.
Care is advisable in patients with myasthenia gravis, who may be at risk of neuromuscular blockade.
Blurred vision after administration is expected. If no improvement within a few days the doctor advice is needed. Tetracycline topical ophthalmic ointment has not a systemic action, in rare cases it may cause irritation of the mucosa. Candidiasis, conjunctivitis are possible mainly due to overgrowth with Candida albicans, and there may be overgrowth of resistant coliform organisms, such as Pseudomonas spp. and Proteus spp. Tetracycline has an anti-anabolic effects on eye mucosa.
Hypersensitivity to the tetracyclines is much less common than to the beta- lactams antibiotics. Hypersensitivity reactions, including rashes, fixed drug eruptions, exfoliative dermatitis are rare possible as the drug usage is not prolonged. Myopia in patients taking tetracyclines may be due to transient hydration of the lens.
The cases of increased muscle weakness in patients with myasthenia gravis and provocation of lupus erythematosus are reported when tetracycline applied for a long time (trachoma).
Sensitivity: Tetracycline should be used with caution in persons with known drug sensitivities.Patients allergic to any tetracycline derivatives may have cross sensitivity to just this ophthalmic drug form.Avoid immediate contact with eyes.
Pregnant Women: No specific problems have been documented.
Pediatrics: No pediatric specific problems have been documented.
Geriatrics: No geriatric specific problems have been documented.
If the dose is mixed, it should be applied as soon as possible or skipped to other next dose.
Don’t use make up with retinoids when tetracyclines are applied.
Ocular inflammation has occurred following the use of ocular preparations preserved with thiomersal in some patients using tetracyclines.
Because of possible antagonism of the action of penicillins by predominantly bacteriostatic tetracyclines it has been recommended that the two types of drug should not be used together, especially when a rapid bactericidal action is necessary.
3 g of ointment for local use is filled into collapsed ophthalmic aluminum tubes (inside package). The tubes are packed and inserted with the leaflet into cardboard boxes (outer package).
3 years. Do not use after the expiration date.
To be dispensed with prescription.
Store in a cool and dry place up at 15°C, out of the reach of children. Protect from light.