Drug form: Liquid (for external use)
ATC category: Agents for pediculosis treatment
Trade name – Antilice International non-property name– Pyrethrins (permethrin+tetramethrin) + Piperonyl butoxide Dosage form Shampoo for external use. Composition Each ml of Antilice shampoo contains: active ingredients: pyrethrins (permethrin + tetramethrin) - 1.65 mg, piperonyl butoxide – 16.5 mg; inactive ingredients: cocamidopropyl betaine, polyquaternium, sodium laureth sulfate, cocamide DEA, sodium chloride, disodium EDTA, methylparaben, citric acid, aroma apple, color «apple green» (E 142), water purified. Pharmacological group and ATC code Pediculicide; P03AC54. Pharmacology Antiliceshampoo is a pediculicide combination. Following absorption through the chitinous exoskeleton of arthropods, pyrethrins stimulate the nervous system, apparently by competitively interfering with cationic conductances in the lipid layer of nerve cells, thereby blocking nerve impulse transmissions. Paralysis and death follow. Piperonyl butoxide has little or no insecticidal activity but potentates that of pyrethrins by inhibiting the hydrolytic enzymes responsible for pyrethrin’s metabolism in arthropods. When piperonyl butoxide is combined with pyrethrins, the insecticidal activity of the latter drug is increased 2-12 times. Spectrum and Resistance Pyrethrins are toxic to the parasitic arthropods Pediculus capitis (head louse), Pediculus corporis (body louse), and Phthirus pubis (crab louse), and possibly their nits. Resistance to pyrethrins may develop rarely in strains of Pediculus corporis. Some lice resistant to chlorophenothane (DDT) have been reported to be cross-resistant to pyrethrins. Pyrethrins are also toxic to house-flies, fleas, chiggers, and mosquitoes. Pharmacokinetics Pyrethrins are absorbed through intact skin when applied topically. Piperоnуl butoxide reportedly is poorly absorbed through intact skin when applied topically. After 24 h after treatment, the concentration of it's components in the blood plasma is minimal, and in some cases is not determined. After 48 h after applying Antilice no traces of its components of the patient's blood plasma is detected. In acute poisoning pyrethrins are inactivated in the digestive tract, and piperonyl butoxide is excreted unchanged in the feces. Uses and administration Antilice is used for pediculosis capitis Administration Antilice shampoo is applied topically. For the treatment of pediculosis capitis, enough shampoo of Antilice should be applied to cover the affected hairy and adjacent areas, taking care to avoid contact with the face (еуеs, eyelashers, or mucous membranes) . After 10 minutes, the hair is then washed thoroughly with water, dried with a clean towel, and combed with а fine tooth comb to remove any remaining nit shells. Although the first treatment with Antilice is often successful, treatment should be repeated after 7-10 days to kill any newly hatched lice. Adverse effects Local reactions: burning, tingling, numbness, swelling, skin rash hairy parts of the body. Contraindications - Pregnancy, breast-feeding. - Hypersensitivity to components of drug. - Childrens up to 2 years of age. Cautions Contact with the face, eyes, mucous membranes, should be avoided. If accidental contact with the eyes occurs, the eyes should be flushed thoroughly with water, Antilice shampoo should not be applied to acutely inflamed skin or raw, weeping surfaces. If primary irritation or hypersensitivity occurs in patients using Antilice shampoo, treatment should be discontinued, the drug washed off, and а physician consulted. Containers of Antilice shampoo should be shaken before using. The drug should not be applied more than once a day. Treatment of patients identified in one outbreak, as well as contact persons should be carried out simultaneously in order to avoid re-infection. All linen must be subjected to thorough processing. Bedding, towels, underwear should be boiled in a solution of detergent for 5-10 min. Outerwear irones on both sides with a hot iron. Things that can not be heat treated, should be hung out outdoors for 3 days. Overdosae Due to the low absorption into the systemic circulation overdose is unlikely. Drug interactions There are no intercations. Identification A greenish viscous liquid with an apple odor. Presentation Shampoo for external use in plastic bottles of 100 ml inserted with the leaflet into cardboard boxes. Expiry date 3 years. Do not use after the expiration date. Prescription status Without prescription. Storage conditions Store in a temperature not higher than 15ºC, out of the reach of children. Protect from light.