Each tablet contains:

active ingredient: metoprolol tartrate – 50 mg

For a full list of excipients, see section 6.1.

Posology

The following dosage regimes are intended only as a guideline and should always be adjusted to the individual requirements of the patient but should not exceed 400 mg/day.

Adults

Hypertension

Initially 100 mg daily. This may be increased, if necessary, to 200 mg daily in single or divided doses. Combination therapy with a diuretic or vasodilator may also be considered to further reduce blood pressure.

Metoprolol may be administered with benefit both to previously untreated patients with hypertension and to those in whom the response to previous therapy is inadequate. In the latter type of patient the previous therapy may be continued and metoprolol added in to the regime with adjustment of the previous therapy if necessary.

Angina pectoris

Usually 50-100 mg two or three times daily. In general, a significant improvement in exercise tolerance and reduction of angina attacks may be expected with a dose of 50-100 mg twice daily.

Cardiac arrhythmias

50 mg two or three times daily is usually sufficient. If necessary, the dose may be increased to 300 mg daily in divided doses.

Following the treatment of an acute arrhythmia with Metoprolol injection, continuation therapy with metoprolol tablets should be initiated 4-6 hours later. The initial oral dose should not exceed 50 mg twice daily.

Myocardial infarctions

Early intervention

Orally, therapy should commence 15 minutes after the last intravenous injection with 50mg every 6 hours for 48 hours and preferably within 12 hours of the onset of chest pain. Patients who fail to tolerate the full i.v. dose should be given half the suggested oral dose.

Maintenance

The usual maintenance dose is 200 mg daily given in divided doses. The treatment should be continued for at least 3 months.

Thyrotoxicosis

50mg four times daily. Dose should be reduced progressively as euthyroid state is achieved.

Prophylaxis of migraine

100 – 200 mg daily in divided doses (morning and evening).

Elderly

The optimum dose should be individually determined according to clinical response. There is no evidence to suggest that dosage requirements are different in otherwise healthy elderly patients. However, caution is indicated in elderly patients as an excessive decrease in blood pressure or pulse rate may cause the blood supply to vital organs to fall to inadequate levels. Dosage should be reduced in the elderly where there is impairment of hepatic function.

Paediatric population

The safety and efficacy of Metoprolol in children has not been established. Metoprolol is not recommended in children.

Hepatic impairment

In patients with significant hepatic dysfunction dosage reduction may be advised.

Reenal impairment

Dose adjustment is not warranted in renal impairment.

Method of Administration

For oral administration.

Pharmacotherapeutic category: Beta blocking agents, selective,

ATC code: C07AB02

List of excipients

Microcrystalline cellulose

Lactose monohydrate

Calcium phosphate dibasic

Povidone

Magnesium stearate

Sodium starch glycolate.

For more detailed information about the drug, click: http://pharm.cals.am/pharm/data/drug_134425/1736329537406.pdf