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Products

    Antilice, shampoo

    Drug formLiquid (for external use)

    ATC categoryAntiparasitic agents

    ATC subcategoryAgents for pediculosis treatment

    Brand nameAntilice

    Generic namePyrethrins (permethrin+tetramethrin)+Piperonyl butoxide

    Dosage form

    Shampoo for external use.

     

    General characteristics

    Main physico-chemical properties

    A greenish viscous liquid with an apple odor.

     

    Composition

    Each ml of Antilice shampoo contains:

    active ingredients: pyrethrins (permethrin + tetramethrin) – 1.65 mg, piperonyl butoxide – 16.5 mg;

    inactive ingredients: cocamidopropyl betaine, polyquaternium, sodium laureth sulfate, cocamide

    DEA, sodium chloride, disodium EDTA, methylparaben, citric acid, aroma apple, color «apple

    green» (E 142), water purified.

     

    Pharmacological group and ATC code

    Pediculicide, P03AC54.

     

    Pharmacologic action

    Antilice shampoo is a pediculicide combination. Antilice destroys nits, larvae and mature individuals of lice.

    Ingredients of Antilice piretrins are neurotoxic toxins for insects. Mechanism of action is partial inhibition of sodium channels inactivation and slowing transmembrane potassium stream in ectoparasite cells, predominantly in neurons. Action of pirethrins is intensified by piperonyl butoxide, which blocks protective ferments released by insects.

    By having different mechanisms of insecticidal action, ingredients of Antilice prevent development of resistance to any of them.

     

    Pharmacokinetics

    In case of external use drug is absorbed to systemic blood flow in insignificant quantity. 24 h after treatment, the concentration of it’s components in the blood plasma is minimal, and in some cases is not determined. 48 h after applying Antilice no traces of its components of the patient’s blood plasma is detected. In acute poisoning pyrethrins are inactivated in the digestive tract, and piperonyl butoxide is excreted unchanged in the feces.

     

    Uses and administration

    Antilice is used for pediculosis capitis.

     

    Administration

    For the treatment of pediculosis capitis, enough shampoo of Antilice should be applied to cover the

    affected hairy and adjacent areas, taking care to avoid contact with the face (еуеs, eyelashers, or

    mucous membranes) . After 10 minutes, the hair is then washed thoroughly with water, dried with a

    clean towel, and combed with а fine tooth comb to remove any remaining nit shells.

    Although the first treatment with Antilice is often successful, treatment should be repeated after 7-

    10 days to kill any newly hatched lice.

    Adverse effects

    Local reactions: burning, tingling, numbness, swelling, skin rash hairy parts of the body.

     

    Contraindications
    • Pregnancy, breast-feeding.
    • Childrens up to 2 years of age.
    • Hypersensitivity to components of drug.

     

    Special precautions

    Caution is needed in patients, who have existing skin diseases.

    Contact with the mucous membranes, nasal passages, oral cavity and external genital organs should be avoided. During manipulation you can protect them with cotton swab (If accidental contact occurs, you should flush thoroughly with water).

    The drug should not be applied more than once a day. Treatment of patients identified in one outbreak, as well as contact persons should be carried out simultaneously in order to avoid reinfection. All linen must be subjected to thorough processing. Bedding, towels, underwear should be boiled in a solution of detergent for 5-10 min. Outerwear irones on both sides with a hot iron. Things that can not be heat treated, should be hung out outdoors for 3 days.

     

    Information about Methylparaben

    Antilice contains methylparaben, which may cause allergic reactions (possibly delayed).

     

    Overdose

    Due to the low absorption into the systemic circulation overdose is unlikely.

     

    Drug interactions

    There are no interactions.

     

    Storage conditions

    Store in a temperature not higher than 15ºC, out of the reach of children. Protect from light.

     

    Expiry date

    3 years. Do not use after the expiration date.

     

    Prescription status

    Without prescription.

     

    Presentation

    90 ml Shampoo for external use in plastic bottle inserted with the leaflet into cardboard box.