Antilice, shampoo

    Drug formLiquid (for external use)

    ATC categoryAntiparasitic agents

    ATC subcategoryAgents for pediculosis treatment

    Brand nameAntilice

    Generic namePyrethrins (permethrin+tetramethrin)+Piperonyl butoxide

    Dosage form

    Shampoo for external use.


    Each ml of Antilice shampoo contains:

    Active ingredient: pyrethrins (permethrin + tetramethrin)-1.65 mg, piperonyl butoxide–16.5 mg;

    Inactive ingredients: cocamidopropyl betaine, polyquaternium, sodium laureth sulfate, cocamide DEA, sodium chloride, disodium EDTA, methylparaben, citric acid, aroma apple, color «apple green» (E 142), water purified.

    Pharmacological group and ATC code

    Pediculicide; P03AC54.


    Pharmacodynamic properties

    Antilice shampoo is a pediculicide combination. Following absorption through the chitinous exoskeleton of arthropods, pyre­thrins stimulate the nervous system, apparently by competitively interfering with cationic conductances in the lipid layer of nerve cells, thereby blocking nerve impulse transmissions. Paralysis and death follow.

    Piperonyl butoxide has little or no insecticidal activity but potentates that of pyrethrins by inhibiting the hydrolytic enzymes responsible for pyrethrin’s metabolism in arthropods. When piperonyl butoxide is combined with pyrethrins, the insecticidal activity of the latter drug is increased 2-12 times.

    Spectrum and Resistance

    Pyrethrins are toxic to the parasitic arthropods Pediculus capitis (head louse), Pediculus corporis (body louse), and Phthirus pubis (crab louse), and possibly their nits. Resistance to pyrethrins may develop rarely in strains of Pediculus corporis. Some lice resistant to chlorophenothane (DDT) have been reported to be cross-resistant to pyrethrins. Pyrethrins are also toxic to house-­flies, fleas, chiggers, and mosquitoes.


    Pyrethrins are absorbed through intact skin when applied topically. Piper­оnуl butoxide reportedly is poorly absorbed through intact skin when applied topically. After 24 h after treatment, the concentration of it’s components in the blood plasma is minimal, and in some cases is not determined. After 48 h after applying Antilice no traces of its components of the patient’s blood plasma is detected. In acute poisoning pyrethrins are inactivated in the digestive tract, and piperonyl butoxide is excreted unchanged in the feces.


    Antilice is used for pediculosis capitis

    Dosage and Administration

    Antilice shampoo is applied topically.

    For the treatment of pediculosis capitis, enough shampoo of Antilice should be applied to cover the affected hairy and adjacent areas, taking care to avoid contact with the face (еуеs, eyelashers, or mucous membranes) . After 10 minutes, the hair is then washed thoroughly with water, dried with a clean towel, and combed with а fine tooth comb to remove any remaining nit shells.

    Although the first treatment with Antilice is often successful, treatment should be repeated after 7-10 days to kill any newly hatched lice.

    Adverse effects

    Local reactions: burning, tingling, numbness, swelling, skin rash hairy parts of the body.

    • Pregnancy, breast-feeding.
    • Hypersensitivity to components of drug.
    • Childrens up to 2 years of age.

    Contact with the face, eyes, mucous membranes, should be avoided. If accidental contact with the eyes occurs, the eyes should be flushed thoroughly with water, Antilice shampoo should not be applied to acutely inflamed skin or raw, weeping surfaces.

    If primary irritation or hypersensitivity occurs in patients using Antilice shampoo, treatment should be discontinued, the drug washed off, and а physician consulted.

    Containers of Antilice shampoo should be shaken before using.

    The drug should not be applied more than once a day. Treatment of patients identified in one outbreak, as well as contact persons should be carried out simultaneously in order to avoid re-infection. All linen must be subjected to thorough processing. Bedding, towels, underwear should be boiled in a solution of detergent for 5-10 min. Outerwear irones on both sides with a hot iron. Things that can not be heat treated, should be hung out outdoors for 3 days.


    Due to the low absorption into the systemic circulation overdose is unlikely.

    Drug interactions

    There are no intercations.

    Prescription status

    To be dispensed without prescription.


    A greenish viscous liquid with an apple odor.


    Shampoo for external use in plastic bottles of 100 ml inserted with the leaflet into cardboard boxes.

    Expiry date

    3 years.

    Storage conditions

    Store in a temperature not higher than 150C, out of the reach of children. Protect from light.