Drug formLiquid (for external use)
ATC categoryAntiparasitic agents
ATC subcategoryAgents for the treatment of scabies
Brand nameBenzyl benzoate
Generic nameBenzyl benzoate
Each ml of Benzyl benzoate 25% emulsion contains:
active ingredient: benzyl benzoate – 250 mg;
excipients: stearic acid, triethanolamine, propylene glycol, glycerin, methylparaben, propylparaben , water purified.
Parasiticidal preparations, antiscabies; P03AX01.
Mechanism of action
Unknown, but in view of the medication’s effects on vertebrates, it is thought that benzyl benzoate may act on the nervous system of the parasite, resulting in its death.
In vitro, benzyl benzoate has been found to kill the Sarcoptes mite within 5 minutes.
No data are available on percutaneous absorption of benzyl benzoate.
If topical benzyl benzoate is systemically absorbed, it is rapidly hydrolyzed to benzoic acid and benzyl alcohol, which is further oxidized to benzoic acid. The benzoic acid is conjugated with glycine to form hippuric acid.
Excreted in the urine primarily as hippuric acid.
Benzyl benzoate is an acaricide used in the treatment of scabies.
The course of treatment lasts for 4 days. On the first day skin treatment is carried out in the evening before going to bed. Children is treated all cutaneous covering and for patients of other age groups face and the hairy part of scalp skin are exceptions . After thorough washing in the shower with warm water and soap patient rubs the emulsion into skin, then the torso and feet, including the soles and toes.
After the treatment, the skin should be used only pure linen (including bed). Treatment break should be on the 2nd and 3rd days and with this the remains of Benzyl benzoate are not being washed from the skin. The patient should wash with soap and rubbing holds in the evening of the 4th day , like the first day, using the remaining emulsion (about 50 ml) and once again change all the linen. After treatment hands should not be washed for 3 hours; subsequently hands should be treated by emulsion after each wash. In case of washing emulsions with other parts of the skin, these parts also must been re-processed. The emulsion should be washed away on the fifth day of treatment. While using the preparation for children it must be diluted with boiled water (for the older children use 1:1 dilution, for newborn infants from 2 months – 1:3), but wherein the effect may be reduced.
Local reactions: may be (especially for children) burning sensation, irritation of the skin.
The preparation is contraindicated for use in children in undiluted form.
Treatment of patients identified in one outbreak, as well as contact persons should be carried out at the same time to avoid re-infection. Treatment of complications of scabies (dermatitis, eczema, pyoderma, postscabiotic lymphoplasy) should be carried out simultaneously with the treatment of scabies and continue after its completion. Saving of itching after treatment is not an indication for the appointment of an additional course of specific therapy. Itching is a reaction of a body to the dead mites and products of its life activity and it disappeares in case of assigning antihistamine preparations and corticosteroid ointments. After treatment requires medical supervision for 2 weeks, and in case of presence of complications – over a more long period of time. Avoid from getting the preparation into the mucous membranes, as it causes severe burning. Young children after treatment wearing babys loose jacket with sewn sleeves.
All linen and other things that cаme into contact with infected skin should be carefully d-bridemented. Bedding, towels, underwear is being boiled in the detergent solution for 5-10 minutes. Outdoor clothing is being pressed on both sides with a hot iron. Things that are not subjected to heat treatment, are posted up in the open air for 3 days.
Solution pharmaceutically incompatible with resorcinol (form melted mixture).
Interactions for preparation Benzyl Benzoate are not described.
120 ml of emultion is filled into amber glass bottles.
A white emultion with a specific odor.
Store at a room temperature (15-250C), in a dry place, out of the reach of children. Protect from light.